Welcome to WineDoctors.com

WineDoctors are committed to transparency and accuracy of information as it relates to moderate wine consumption. Our goal is to present and develop an interactive understanding and enjoyment of wine. In vino sanitas! Read more

Our Philosophy

Our wines are made in limited production from premium grape sources. Wine-making is a creative, dynamic, and scientific process. Our wines are meant to be enjoyed with regular meals, and as a result, allow the fruit to show its natural excellence.
Read more

http://winedoctors.com/components/com_gk2_photoslide/images/thumbm/954415wdw_home_short_1.png http://winedoctors.com/components/com_gk2_photoslide/images/thumbm/792835wdw_home_short_2.png
Impact of Alcohol on Cancer PDF Print E-mail
Wednesday, 20 February 2013 18:38

The airwaves have been abuzz over a recent publication concerning the negative impact of alcohol on cancer-related deaths. The results of the article in the American Journal of Public Health confirm results of other studies. The WineDoctors would like to review the relationship between alcohol and cancer and focus on the impact of alcohol on breast and head and neck cancers.

Ethanol has been classified as the most important carcinogen in alcoholic beverages. The epidemiological evidence of the carcinogenicity
of alcoholic beverage consumption
shows little indication that alcohol’s
carcinogenic effects depend on the type of alcoholic beverage. A linear association has been noted for average daily alcohol consumption and cancer risk. There is a clear dose response meaning that the more alcohol one consumes, the higher that individual’s cancer risk. Some other compounds found in wine (lead, arsenic, ethyl carbamate, acetaldehyde) may pose risks below thresholds normally tolerated for food contaminants.

Worldwide in 2002, about 389 100 cases of cancer were attributable to alcohol drinking—3·6% of all cancers, and 232 900 deaths from cancer deaths were attributable to alcohol consumption—3·5% of all cancer deaths. A causal link has been established between alcohol consumption and cancer of the upper aerodigestive tract (ie, of the oral cavity, pharynx, or esophagus); liver; colon; rectum; and breast. An association has been observed between alcohol consumption and cancer of the pancreas. There is evidence suggesting lack of carcinogenicity for cancer of the kidney and non-Hodgkin lymphoma.

Breast CA
Large cohorts of postmenopausal women have been evaluated, indicating a link between estrogen receptor positive cancers, but not triple negative cancers with regard to alcohol consumption.  Data suggests that genetic/familial cancers testing positive for BRCA1 and 2 markers show no association with alcohol use. Precancer or DCIS has no association with alcohol use. However, women who consume alcohol and have hormonally sensitive estrogen receptor positive or progesterone receptor positive cancers might be prone to an increased risk of recurrence. This has to be weighed with the information that moderate alcohol consumption may have a cardio-protective effect in these patients.

The above associations do suggest a different physiologic basis for occurrence. Proposed mechanisms of action might include increased rates of circulating estrogen in women who consume alcohol in the menopause and possible additive effect with higher levels of circulating estrogen even in menopause in obese women.

Head and Neck CA
A clinical link between the chronic consumption of alcohol and head and neck cancer has been observed for decades. Alcohol was described initially as a risk enhancer only in smokers. A number of epidemiological studies have now provided sufficient evidence that chronic alcohol consumption increases the risk of head and neck cancer independent of exposure to tobacco smoke. The systemic effects of alcohol interact with local changes in the morphology and function of the salivary glands. In addition, alcohol leads to accumulation of pathologic microbes within the mucosa, leading to chronic infection.

Acetaldehyde is a metabolite of alcohol oxidation is derived either from ethanol or tobacco and appears to act in the upper digestive tract as a local carcinogen in a dose-dependent and synergistic way. There us strong epidemiological, biochemical and genetic evidence supporting the role of the first metabolite of alcohol oxidation--acetaldehyde--as a common denominator. Acetaldehyde has direct carcinogenic and mutagenic effects by modifying DNA

ALDH2-deficiency and high active ADH1C result in two- to threefold salivary acetaldehyde concentrations after a dose of alcohol and this prevails for as long as ethanol is present in the blood and saliva. Alcohol is metabolized to acetaldehyde locally in the oral cavity by microbes representing normal oral flora. Poor oral hygiene, heavy drinking and chronic smoking modify oral flora to produce more acetaldehyde from ingested alcohol. Also, tobacco smoke contains acetaldehyde, which during smoking becomes dissolved in saliva. Via swallowing, salivary acetaldehyde of either origin is distributed from oral cavity to pharynx, esophagus and stomach.

 

Spotlight

WineDoctors in the News: Alcohol and Hypertension

from the International Scientific Forum on Alcohol Research - Critique 101: A review of the association of alcohol consumption with the risk of developing hypertension — 22 January 2013
Briasoulis A, Agarwal V, Messerli FH.  Alcohol consumption and the risk of hypertension in men and women:  A systematic review and meta-analysis.  J Clin Hypertens 2012;14:792-798.
Authors’ Abstract
Heavy alco [ ... ]


The Doctors Are In

Positive Effect of Moderate Alcohol Consumption on Diabetes

MB asks: Why do diabetics who drink moderately have improved blood glucose control?

WineDoctors’ response:
Alcohol is considered a nutrient because it has caloric value.  Carbohydrates have 4kcal/gm; proteins have 4kcal/gm; alcohol has 7kcal/gram and; fat has 9 kcal/gram.  Remember that the body cannot store alcohol.  Alcohol calories are used first over calories from other sources.

Alcohol is metabolized via the carbohydrate/glucose pathway.  The first step in the metabolism of digestible carbohydrate is the conversion of complex carbohydrates to simpler, soluble forms that can be transported across the intestinal wall and delivered to the tissues.  Insulin is a hormone produced by the pancreas.  It regulates our blood glucose levels.  One of the ways insulin does this is by stim [ ... ]


More News

Alcohol-Attributable Cancer Deaths and Years of Potential Life Lost in the United States.

Alcohol-Attributable Cancer Deaths and Years of Potential Life Lost in the United States.
Nelson DE, Jarman DW, Rehm J, Greenfield TK, Rey G, Kerr WC, Miller P, Shield KD, Ye Y, Naimi TS.

Abstract
Object [ ... ]


The effect of different alcohol drinking patterns in early to mid pregnancy on the child's intelligence, attention, and executive function.

BJOG. 2012 Jun 20. [Epub ahead of print]

Kesmodel U, Bertrand J, Støvring H, Skarpness B, Denny C, Mortensen E; the Lifestyle During Pregnancy Study Group.

Abstract
The Lifestyle During Pregnancy Study [ ... ]


The effects of low to moderate alcohol consumption and binge drinking in early pregnancy on executive function in 5-year-old children.

BJOG. 2012 Jun 20. [Epub ahead of print]

Skogerbø A, Kesmodel U, Wimberley T, Støvring H, Bertrand J, Landrø N, Mortensen E.

Abstract
The effects of low to moderate alcohol consumption and binge drin [ ... ]


The effects of low to moderate alcohol consumption and binge drinking in early pregnancy on selective and sustained attention in 5-year-old children.

BJOG. 2012 Jun 20. [Epub ahead of print]

Underbjerg M, Kesmodel U, Landrø N, Bakketeig L, Grove J, Wimberley T, Kilburn T, Svaerke C, Thorsen P, Mortensen E.

Abstract
The effects of low to moderate alc [ ... ]


The effects of low to moderate prenatal alcohol exposure in early pregnancy on IQ in 5-year-old children.

BJOG. 2012 Jun 20. [Epub ahead of print]

Falgreen Eriksen HL, Mortensen E, Kilburn T, Underbjerg M, Bertrand J, Støvring H, Wimberley T, Grove J, Kesmodel U.

Abstract
The effects of low to moderate pren [ ... ]


Poll

I would try more red wine if I knew the maker made special efforts to help me avoid a wine headache.
 

RSS | Syndicate

follow us on twitter