Arthur L. Klatsky, MD is a Senior Consultant in Cardiology and an Adjunct Investigator at the Division of Research at the Kaiser Permanente Medical Center, Oakland, California.  He has done ext [ ... ]

Michelle Brandt, Senior Communication Manager, Stanford University School of Medicine asked the WineDoctors to comment on a recent article published in Nature magazine on January 19, 2010, entitled: Health benefits of red-wine chemical unclear.1 Background. In 2007, Christopher Wesphal et al, reported that resveratrol directly activated sirtuin-1 (SIRT1). SIRT1 is a mediator of the pathways involved in calorie restriction that have been shown to delay the onset and reduce the incidence of age-related diseases such as type 2 diabetes. Westphal et al. identified 3 compounds that were 1000 times more potent than resveratrol called Sirtuis compounds. These compounds are now in Phase II clinical trials for treatment of Diabetes Mellitus type II and one for cancer. A recent study publish [ ... ]