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Further support of obesity surgery slowing ethanol metabolism |
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Obes Surg. 2010 Apr 1. [Epub ahead of print]
Alcohol Absorption Modification After a Laparoscopic Sleeve Gastrectomy Due to Obesity.
Maluenda F, Csendes A, De Aretxabala X, Poniachik J, Salvo K, Delgado I, Rodriguez P.
Department of Surgery, German Clinic of Santiago, Santiago, Chile,
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BACKGROUND: The different bariatric surgery techniques that alter the digestive anatomy also modify the gastric absorption surface. Since alcohol is a substance that is mainly metabolized in the stomach, the goal of this study was to determine alcohol absorption before and after a laparoscopic sleeve gastrectomy (LSG) in the same patients. METHODS: Studies were carried out on 12 morbidly obese patients who underwent a LSG (eight men and four women). Each patient was given 3.6 ml of red wine to drink at 14% for each liter of body water mass. Alcotest values (Alcoscan Alcomate AL-6000) were measured 10 min after the wine dose had been consumed. Measurements were then repeated every 5 min until the alcohol had been completely eliminated from the bloodstream. During the postoperatory period (median of 2.3 months), the measurement was repeated with the total dose per kg adjusted to the new water body mass. The results were measured with a nonparametric analysis for repeated samples. RESULTS: The maximum average peak of the Alcotest was 2.02 g/l during the postoperative period compared to 0.87 g/l during the preoperative period (p = 0.001 Wilcoxon). At 175 min, the blood alcohol level value reaches zero (0) in all pre-operatory patients, while after surgery, an average value of 0.26 g/l was observed (p = 0.027 Wilcoxon). After 4 h, an Alcotest average of 0.20 g/l was observed in these patients. CONCLUSION: Alcohol absorption was considerably modified after LSG with higher and longer blood alcohol values for equivalent amounts of alcohol.
PMID: 20358306 [PubMed - as supplied by publisher]
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Key molecule identified in alcohol metabolism |
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Nat Struct Mol Biol. 2010 Jan 10. [Epub ahead of print]
Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant.
Investigators from Indiana University identified a key molecule in alcohol metabolism. In the future, this may have implications on prevention and treatment of cardiovascular disease and improved alcohol tolerance in one billion people, mainly Asians.
Perez-Miller S, Younus H, Vanam R, Chen CH, Mochly-Rosen D, Hurley TD.
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
In approximately one billion people, a point mutation inactivates a key detoxifying enzyme, aldehyde dehydrogenase (ALDH2). This mitochondrial enzyme metabolizes toxic biogenic and environmental aldehydes, including the endogenously produced 4-hydroxynonenal (4HNE) and the environmental pollutant acrolein, and also bioactivates nitroglycerin. ALDH2 is best known, however, for its role in ethanol metabolism. The accumulation of acetaldehyde following the consumption of even a single alcoholic beverage leads to the Asian alcohol-induced flushing syndrome in ALDH2*2 homozygotes. The ALDH2*2 allele is semidominant, and heterozygotic individuals show a similar but less severe phenotype. We recently identified a small molecule, Alda-1, that activates wild-type ALDH2 and restores near-wild-type activity to ALDH2*2. The structures of Alda-1 bound to ALDH2 and ALDH2*2 reveal how Alda-1 activates the wild-type enzyme and how it restores the activity of ALDH2*2 by acting as a structural chaperone.
PMID: 20062057 [PubMed - as supplied by publisher] |
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During the holiday season, wine consumption increases significantly compared to all other seasons. How quickly our body metabolizes wine is very dependent on multiple factors, including whether it is consumed with food and which types, gender, body weight, ethnicity, alcohol concentration, whether it is carbonated and the rate at which it is consumed. Tobacco consumption, physical activity (dancing) and if you are on any other medications will have significant impact on the rate of metabolism.
The human body doesn’t store alcohol calories and metabolizes these calories before any others. A typical glass of red wine has 125 calories for 5 ounces, while a glass of white has 120 kcal. Alcohol in general has 7kcal/grams as compared with carbs and proteins at 4kcal/gram and fats at 9kcal/gram. In general, we metabolize fats the slowest and carbs the quickest. 20% of alcohol gets absorbed in the stomach, while 80% gets absorbed in the small intestines. So as an example, if wine is consumed with cheese and crackers, the absorption rate will be less than if consumed just with the crackers alone. Blood alcohol levels will be lower if alcohol is absorbed more slowly.
Safe consumption during the holidays is also an area of interest as we hop from party to party. In general, the number of hours it takes to metabolize a standard drink (12 ounces of beer at 5% alcohol; 1 1/2-oz shot at 40% alcohol; or 5 ounce glass of wine at 12% alcohol) will take a 150 lb individual about 1 hour 20 minutes to metabolize.
The Winedoctors wish everyone a cheerful and safe holiday season! |
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