Alcohol had an inverse association with the risk of lymphoid neoplasms PDF Print E-mail

Cancer Epidemiol Biomarkers Prev. 2010 Jan 19. [Epub ahead of print]

Association of Alcohol Intake with the Risk of Malignant Lymphoma and Plasma Cell Myeloma in Japanese: A Population-Based Cohort Study (Japan Public Health Center-based Prospective Study).

Kanda J, Matsuo K, Inoue M, Iwasaki M, Sawada N, Shimazu T, Yamaji T, Sasazuki S, Tsugane S; Japan Public Health Center–based Prospective Study Group.

Authors' Affiliations: 1Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute and 2Department of Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan; 3Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan; and 4Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Few studies have evaluated the association between alcohol intake and the risk of the lymphoid neoplasms malignant lymphoma (ML) and plasma cell myeloma (PCM) among Asian populations. We conducted a large-scale population-based cohort study of 95,520 Japanese subjects (45,453 men and 50,067 women; age 40-69 years at baseline) with an average 13 years of follow-up, during which a total of 257 cases of ML and 89 of PCM were identified. Hazard ratios and 95% confidence intervals were estimated using a Cox regression model adjusted for potential confounders. Alcohol intake of >/=300 g/week was associated with a significantly lower risk of lymphoid neoplasms (hazard ratio, 0.60; 95% confidence interval, 0.37-0.98) than occasional drinking at a frequency of <1 day/month, and the trend for alcohol consumption was significant (P = 0.028). A similar trend was observed for the subcategories of ML, PCM, and non-Hodgkin lymphoma (NHL), albeit that the results were significant only for alcohol consumption at >/=300 g/week in NHL patients, probably due to the small number of subjects in each category. In conclusion, we found that alcohol had an inverse association with the risk of lymphoid neoplasms, particularly the risk of NHL, among a Japanese population. Cancer Epidemiol Biomarkers Prev; 19(2); OF1-6.


Alcohol intake and risk of thyroid cancer PDF Print E-mail

Br J Cancer. 2009 Nov 3;101(9):1630-4. Epub 2009 Sep 29.

Alcohol intake and risk of thyroid cancer in the NIH-AARP Diet and Health Study.

Meinhold CL, Park Y, Stolzenberg-Solomon RZ, Hollenbeck AR, Schatzkin A, Berrington de Gonzalez A.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120Executive Boulevard, Rockville, MD 20852, USA. This e-mail address is being protected from spambots. You need JavaScript enabled to view it

BACKGROUND: Certain studies suggest that alcohol may reduce the risk of thyroid cancer in women, but the effect in men remains unclear. METHODS: We analysed the association between alcohol and thyroid cancer in a large (n=490 159) prospective NIH-AARP Diet and Health Study with self-reported beer, wine, and liquor intakes. RESULTS: Over 7.5 years of follow-up (median), 170 men and 200 women developed thyroid cancer. Overall, the thyroid cancer risk decreased with greater alcohol consumption (> or =2 drinks per day vs none, relative risk=0.57, 95% CI 0.36-0.89, P-trend=0.01). CONCLUSIONS: These results suggest a potential protective role for alcohol consumption in thyroid cancer.

PMCID: PMC2778506 [Available on 2010/11/3]




Baseline alcohol consumption, type of alcoholic beverage and risk of colorectal cancer PDF Print E-mail

Cancer Epidemiol. 2009 Nov;33(5):347-54. Epub 2009 Nov 22.

Baseline alcohol consumption, type of alcoholic beverage and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition-Norfolk study.

Park JY, Mitrou PN, Dahm CC, Luben RN, Wareham NJ, Khaw KT, Rodwell SA. Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK. This e-mail address is being protected from spambots. You need JavaScript enabled to view it

Excessive alcohol consumption has been associated with increased risk of colorectal cancer (CRC). However, the effect of modest alcohol consumption or of particular types of beverages on CRC risk remains unclear. We examined whether consumption of total alcohol or specific types of alcoholic beverages relate to overall or site-specific CRC risk in a prospective population study of 24,244 participants and 407 incident CRC cases after 11 years of follow-up. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models. Consumption of specific alcoholic beverages at baseline was collected using a detailed health and lifestyle questionnaire. Total alcohol consumption was not associated with CRC risk before or after adjustment for age, sex, weight, height, and smoking status (HR: 0.80, 95% CI: 0.51-1.26 for alcohol consumption of > or =21 units/week compared with non-drinkers), and further adjustment for education level, exercise, family history of CRC, and dietary factors did not significantly alter the risk estimates (HR: 0.70, 95% CI: 0.44-1.13). No significant associations were observed between consumption of specific alcoholic beverages (beer, sherry, or spirits) and CRC risk when compared with non-drinkers after adjustment for lifestyle and dietary factors. Daily consumption of > or =1 unit of wine appeared inversely related to CRC risk (HR: 0.61, 95% CI: 0.40-0.94). No evidence was found for sex-specific relationships, and further exclusion of cases incident within 3 years of baseline did not change the associations observed. In this population-based UK cohort, we did not find any significant adverse effect of alcohol over the moderate range of intake on colorectal cancer risk.

PMID: 19932648 [PubMed - in process]

Fluid intake and the risk of bladder cancer PDF Print E-mail

Int J Cancer. 2009 Dec 2. [Epub ahead of print]

Fluid intake and the risk of bladder cancer: Results from the South and East China case-control study on bladder cancer.

Hemelt M, Hu ZQ, Zhong Z, Xie LP, Wong YC, Tam PC, Cheng KK, Ye ZQ, Bi XC, Lu Q, Mao YQ, Zhong WD, Zeegers MP.  Unit of Genetic Epidemiology. Department of Public Health, Epidemiology & Biostatistics. University of Birmingham, Birmingham, UK.

Although several studies have assessed the association between total fluid intake, specific drinks and bladder cancer, no firm conclusions can yet be drawn. 432 bladder cancer cases and 392 frequency matched hospital-based controls recruited in the South and East of China between October 2005 and June 2008 were interviewed on their intake of six non-alcoholic and three alcoholic drinks. Age, sex, smoking, and hospital adjusted odds ratios (OR) and 95 percent confidence intervals (95% CI) were calculated for all drinks and for total fluid intake using logistic regression. For 381 cases (81.9% men) and 371 controls (76.3% men) total fluid intake could be calculated. In men, an increase in total fluid intake was associated with a significantly decreased bladder cancer risk (OR 0.93, 95% CI: 0.88-0.99, per cup fluid consumed). Neither green nor black tea consumption was associated with bladder cancer. Daily consumption of milk significantly reduced the risk of bladder cancer by a half (OR 0.49, 95% CI: 0.32-0.76), which strengthens earlier suggestions that milk is probably associated with a decreased bladder cancer risk. Consumption of wine (OR 0.49, 95% CI: 0.34-0.70) and liquor/spirits (OR 0.65, 95% CI: 0.47-0.92) were associated with a significantly reduced risk. Consumption of water, fruit juice and beer appeared not associated with bladder cancer. There is no clear indication that the risks observed in this Chinese population are substantially different from those observed in Caucasian populations. (c) 2009 UICC.

PMID: 19957334 [PubMed - as supplied by publisher]



Alcohol consumption and non-Hodgkin lymphoma survival PDF Print E-mail

J Cancer Surviv. 2009 Dec 29. [Epub ahead of print]

Alcohol consumption and non-Hodgkin lymphoma survival.

Han X, Zheng T, Foss FM, Ma S, Holford TR, Boyle P, Leaderer B, Zhao P, Dai M, Zhang Y. School of Public Health, Yale University, New Haven, CT, 06520, USA.

INTRODUCTION: Epidemiological studies have shown that moderate alcohol drinkers have a lower death rate for all causes. Alcohol drinking has also been associated with reduced risk of non-Hodgkin lymphoma (NHL). Here, we examined the role of alcohol consumption on NHL survival by type of alcohol consumed and NHL subtype. METHODS: A cohort of 575 female NHL incident cases diagnosed during 1996-2000 in Connecticut was followed-up for a median of 7.75 years. Demographic, clinical, and lifestyle information was collected at diagnosis. Survival analyses were conducted with Kaplan-Meier methods, and hazard ratios (HR) were estimated from Cox Proportional Hazards models. RESULTS: Compared to never drinkers, wine drinkers experienced better overall survival (75% vs. 69% five-year survival rates, p-value for log-rank test = 0.030) and better disease free survival (70% vs. 67% five-year disease-free survival rates, p-value for log-rank test = 0.049). Analysis by NHL subtype shows that the favorable effect of wine consumption was mainly seen for patients diagnosed with diffuse large B-cell lymphoma (DLBCL) (wine drinkers for more than 25 years vs. never drinkers: HR = 0.36, 95% CI 0.14-0.94 for overall survival; HR = 0.38, 95% CI 0.16-0.94 for disease-free survival), and the adverse effect of liquor consumption was also observed among DLBCL patients (liquor drinkers vs. never drinkers: HR=2.49, 95% CI 1.26-4.93 for disease-free survival). CONCLUSIONS: Our results suggest a moderate relationship between pre-diagnostic alcohol consumption and NHL survival, particularly for DLBCL. The results need to be replicated in larger studies. IMPLICATIONS FOR CANCER SURVIVORS: Pre-diagnostic behaviors might impact the prognosis and survival of NHL patients.

PMID: 20039144 [PubMed - as supplied by publisher]




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