cardiovascular health

Valentine's Day: Reflections on Heart Health PDF Print E-mail

Moderate Wine Consumption and Recent Heart Attack PDF Print E-mail

Mol Nutr Food Res. 2011 Oct 31. doi: 10.1002/mnfr.201100336. [Epub ahead of print]
A moderate red wine intake improves blood lipid parameters and erythrocytes membrane fluidity in post myocardial infarct patients.
Rifler JP, Lorcerie F, Durand P, Delmas D, Ragot K, Limagne E, Mazué F, Riedinger JM, d'Athis P, Hudelot B, Prost M, Lizard G, Latruffe N.
INSERM UMR 866 - LBMN, Université de Bourgogne, Dijon, France; C.H. Montbard, rue Auguste Carré, Montbard, France.
While the cardioprotective effect of moderate and regular wine consumption in primary prevention has been well documented, the goal of the present investigation was to explore the effect of wine intake on blood parameters (lipid, anti-oxidant capacity, and erythrocyte membrane potential and fluidity) in post myocardial infarct patients to evaluate perspectives in secondary prevention. A clinical intervention trial has been undertaken on a group of selected post myocardial infarct patients who gave written informed consent for participation in this study prior to enrolment. This two-week study has been conducted on hospitalized patients during a cardiac readaptation period. During this period, patients were submitted to a "Western prudent" diet (inspired by the Mediterranean diet) and two groups have been compared on a drawn basis: patients receiving red wine (250 mL daily) to patients receiving water. Physical, clinical, and blood parameters were evaluated on Days 1 and 14. The data show a positive effect of low wine consumption on blood parameters (decrease in total cholesterol and LDL; increase in erythrocyte membrane fluidity and antioxidant status). The results show that a moderate consumption of red wine even for a short period associated with a "Western prudent" diet improves various blood parameters in lipid and anti-oxidative status in patients with previous coronary ischemic accidents.
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Impact of Grape seeds on Cardiovascular health PDF Print E-mail

PLoS One. 2011;6(12):e28460. Epub 2011 Dec 8.
Pleiotropic benefit of monomeric and oligomeric flavanols on vascular health - a randomized controlled clinical pilot study.
Weseler AR, Ruijters EJ, Drittij-Reijnders MJ, Reesink KD, Haenen GR, Bast A.
Department of Toxicology, Maastricht University, Maastricht, The Netherlands.
Cardiovascular diseases are expanding to a major social-economic burden in the Western World and undermine man's deep desire for healthy ageing. Epidemiological studies suggest that flavanol-rich foods (e.g. grapes, wine, chocolate) sustain cardiovascular health. For an evidenced-based application, however, sound clinical data on their efficacy are strongly demanded.
In a double-blind, randomized, placebo-controlled intervention study we supplemented 28 male smokers with 200 mg per day of monomeric and oligomeric flavanols (MOF) from grape seeds. At baseline, after 4 and 8 weeks we measured macro- and microvascular function and a cluster of systemic biomarkers for major pathological processes occurring in the vasculature: disturbances in lipid metabolism and cellular redox balance, and activation of inflammatory cells and platelets.
In the MOF group serum total cholesterol and LDL decreased significantly (P≤0.05) by 5% (n = 11) and 7% (n = 9), respectively in volunteers with elevated baseline levels. Additionally, after 8 weeks the ratio of glutathione to glutathione disulphide in erythrocytes rose from baseline by 22% (n = 15, P<0.05) in MOF supplemented subjects. We also observed that MOF supplementation exerts anti-inflammatory effects in blood towards ex vivo added bacterial endotoxin and significantly reduces expression of inflammatory genes in leukocytes. Conversely, alterations in macro- and microvascular function, platelet aggregation, plasma levels of nitric oxide surrogates, endothelin-1, C-reactive protein, fibrinogen, prostaglandin F2alpha, plasma antioxidant capacity and gene expression levels of antioxidant defense enzymes did not reach statistical significance after 8 weeks MOF supplementation. However, integrating all measured effects into a global, so-called vascular health index revealed a significant improvement of overall vascular health by MOF compared to placebo (P≤0.05).
Our integrative multi-biomarker approach unveiled the pleiotropic vascular health benefit of an 8 weeks supplementation with 200 mg/d MOF in humans.

J-shaped curve applies to wine AND beer! PDF Print E-mail

Wine, beer or spirit drinking in relation to fatal and non-fatal cardiovascular events: a meta-analysis.

Eur J Epidemiol. 2011 Nov;26(11):833-50. Epub 2011 Nov 11.

In previous studies evaluating whether different alcoholic beverages would protect against cardiovascular disease, a J-shaped relationship for increasing wine consumption and vascular risk was found; however a similar association for beer or spirits could not be established. An updated meta-analysis on the relationship between wine, beer or spirit consumption and vascular events was performed. Articles were retrieved through March 2011 by PubMed and EMBASE search and a weighed least-squares regression analysis pooled data derived from studies that gave quantitative estimation of the vascular risk associated with the alcoholic beverages. From 16 studies, evidence confirms a J-shaped relationship between wine intake and vascular risk. A significant maximal protection-average 31% (95% confidence interval (CI): 19-42%) was observed at 21 g/day of alcohol. Similarly, from 13 studies a J-shaped relationship was apparent for beer (maximal protection: 42% (95% CI: 19-58%) at 43 g/day of alcohol). From 12 studies reporting separate data on wine or beer consumption, two closely overlapping dose-response curves were obtained (maximal protection of 33% at 25 g/day of alcohol). This meta-analysis confirms the J-shaped association between wine consumption and vascular risk and provides, for the first time, evidence for a similar relationship between beer and vascular risk. In the meta-analysis of 10 studies on spirit consumption and vascular risk, no J-shaped relationship could be found.

Impact of Wine on Cholestrol PDF Print E-mail

J Agric Food Chem. 2011 May 18. [Epub ahead of print]
Red and White Wines Inhibit Cholesterol Oxidation Induced by Free Radicals.
Tian L, Wang H, Abdallah AM, Prinyawiwatkul W, Xu Z.
College of Enology, Northwest A&F University , Shaanxi, Yangling 712100, China.
The capabilities of two red (RW) and two white wines (WW) in inhibiting cholesterol oxidation were evaluated using a cholesterol emulsion (CE) system. Each RW or WW was mixed with CE at different (v/v) ratios. Cholesterol oxidation was accelerated by a free radical generator, 2,2'-azobis(2-methylpropionamidine) dihydrochloride (AAPH), at 37 °C. The major oxidation product, 7-ketocholesterol, was monitored to determine cholesterol stability in the CE system. At a ratio of 1:250 (RW/CE), 7-ketocholesterol production was not detected during 72 h of oxidation. At a 1:1000 ratio, the inhibition rate of each RW was maintained at 100% at 24 h but decreased afterward. Both WWs had 100% inhibition rate within 48 h at a ratio of 1:10. Also, the capabilities of catechin and resveratrol solutions (1 mg/mL) in inhibiting cholesterol oxidation were studied. Each of the wine polyphenolics showed a 100% of 7-ketocholesterol inhibition rate in 24 h at a ratio of 1:500 (solution/CE). However, the inhibition rate of resveratrol was lower than that of catechin at 48 or 72 h. The results demonstrated that red wine possesses great anti-cholesterol-oxidation capability, which may contribute to health benefits in preventing cardiovascular diseases. Catechin may play a more important role than resveratrol in inhibiting cholesterol oxidation.
[PubMed - as supplied by publisher]


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